Search results for " nucleic acid based drugs"

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Inulin Derivatives Obtained Via Enhanced Microwave Synthesis for Nucleic Acid Based Drug Delivery

2015

A new class of therapeutic agents with a high potential for the treatment of different socially relevant human diseases is represented by Nucleic Acid Based Drugs (NABD), including small interfering RNAs (siRNA), decoy oligodeoxynucleotides (decoy ODN) and antisense oligonucleotides (ASOs). Although NABD can be engineered to be specifically directed against virtually any target, their susceptibility to nuclease degradation and the difficulty of delivery into target tissues severely limit their use in clinical practice and require the development of an appropriate nanostructured delivery system. For delivery of NABD, Inulin (Inu), a natural, water soluble and biocompatible polysaccharide, wa…

siRNA deliverymicrowavespermineSettore CHIM/09 - Farmaceutico Tecnologico Applicativopolyplexnucleic acid based drugsInulin; microwave; nucleic acid based drugs; polyplex; siRNA delivery; spermineInulinInulin microwave nucleic acid based drugs polyplex siRNA delivery spermine

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PEPhysical Sciences and Engineering
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LSLife Sciences
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